IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant murine IL-31 is a 15.8 kDa protein containing 140 amino acid residues.
Store in -20°c for long term storage. After reconstitution, store in 4°c for short term usage within a few days. Avoid freeze-thaw cycles.
- category: Recombinant Proteins
- gene name: Il31
- contents: Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.
- uniprot_id: Q6EAL8
- form: Solid
- white powder or thin/invisible film
- purification: NA
- applications: Cell Culture
- subcellular_localization: Secreted .
- source: E. Coli
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