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ELISA kit for Mouse Serine/threonine-protein kinase DCLK1 (DCLK1)

Supplier Abbkine · Catalog number: KTE71328-48T

Price

332.00EUR

Size
48T

Quantitative sandwich ELISA for measuring Mouse Serine/threonine-protein kinase DCLK1 (DCLK1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

  • Additional information:Doublecortin-like kinase 1 (Dclk1)  encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
  • Storage and shipping:All of the components are shipped on ice packs/blue ice. Upon receiving the kit keep it at +4 degrees Celsius for up to 1 year (refer to the label on the box for the exact expiration date).
  • Notes:This kit is intended for research use only. It should not be used for human or animal clinical diagnostics or treatment.

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