Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
- Tested Applications: E, WB
- Applications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.3 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Predicted Molecular Weight: 37.3 kDa
- Physical state: Lyophilized
- Buffer: 5 mM HAC,100 mM NaCl, pH 5.5
- Concentration: N/A
- NCBI official symbol: N/A
- Accession #: N/A
- Protein GI: N/A
- NCBI gene ID#: N/A
- NCBI official full name: N/A
- NCBI organism: N/A
- Peptide sequence: N/A
- SWISSPROT #: N/A
- Background Reference 1: Faith Hall-Glenn., et al. 2011, Cell Mol Life Sci., 68(19), 3209–3217.
- Background Reference 2: Nakanishi T., et al. 2000, Endocrinology., 141(1), 264-73.
- Background Reference 3: Ball DK., et al. 2000, J Endocrinol., 176(2), R1-7.
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: HEK293 cells
- Species: Rhesus monkey
- By Source: Human Cells
- By Species: Other
- Fusion tag: His Tag
- Sequence: Gln 27 - Ala 349
- Biology activity: N/A
- Purity: >90% as determined by SDS-PAGE.
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