Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
- Tested Applications: N/A
- Applications: Immunogen
- Predicted Molecular Weight: 42.71kDa
- Physical state: Lyophilized
- Buffer: Supplied as lyophilized from PBS, pH 7.5, 0.02%NLS. Please reconstitute the protein with ddH2O to the concentration with 1mg/ml.
- Concentration: N/A
- NCBI official symbol: N/A
- Accession #: NP_001358344.1 or Uniprot Q9BYF1
- Protein GI: N/A
- NCBI gene ID#: N/A
- NCBI official full name: N/A
- NCBI organism: N/A
- Peptide sequence: N/A
- SWISSPROT #: N/A
- Background Reference 1: N/A
- Background Reference 2: N/A
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: E. coli
- Species: Human
- By Source: E. coli
- By Species: Other
- Fusion tag: N-His Tag
- Sequence: Leu392-Ser740
- Biology activity: N/A
- Purity: >90% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue Staining.
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
0 reviews for ProSci