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Pubmed ID :30348695
Publication Date : //

Soluble Thrombomodulin Attenuates Endothelial Cell Damage in Hepatic Sinusoidal Obstruction Syndrome.


Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease, is a form of drug-induced liver injury, the initial morphological changes associated with which occur in liver sinusoidal endothelial cells (LSECs). Recombinant human soluble thrombomodulin (rTM) is reported to have anti-inflammatory and cytoprotective effects. Therefore, we investigated the ability of rTM to protect endothelial cells and enhance their functions in a monocrotaline (MCT)-induced model of SOS.

Authors : Takada Satoshi , Miyashita Tomoharu , Yamamoto Yasuhiko , Kanou Shunsuke , Munesue Seiichi , Ohbatake Yoshinao , Nakanuma Shinichi , Okamoto Koichi , Sakai Seisho , Kinoshita Jun , Makino Isamu , Nakamura Keishi , Tajima Hidehiro , Takamura Hiroyuki , Ninomiya Itasu , Fushida Sachio , Ohta Tetsuo ,

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