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Pubmed ID :30308514
Publication Date : //

Psoriasis Treatment Changes the Expression Profile of Selected Caspases and their Regulatory MicroRNAs.


Psoriasis, an autoimmune diseases of the skin, characterized by patches of abnormal/inflammed skin, although not usually life-threatening, it causes severe discomfort, esthetic impairments, and may lead to impaired social functions and social withdrawal. Besides UV-phototherapy, various anti-inflammatory treatments are applied, depending on the severity of symptoms. In 2008, adalimumab (fully humanized human anti-TNF antibody) was launched for the treatment of psoriasis. In the quest to better understand the pathomechanism of adalimumab's therapeutic effects, and the acquired resistance to the drug, we have investigated how its administration affect the regulation of the expression of selected caspases, including those activated by inflammosome.

Authors : Wcisło-Dziadecka Dominika , Simka Klaudia , Kaźmierczak Agata , Kruszniewska-Rajs Celina , Gola Joanna , Grabarek Beniamin , Hybiak Jolanta , Grillon Catherine , Mazurek Urszula , Łos Marek J ,

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