Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :30157491
Publication Date : //

Pigment Epithelium-Derived Factor and its Phosphomimetic Mutant Induce JNK-Dependent Apoptosis and P38-Mediated Migration Arrest.


Pigment epithelium-derived factor (PEDF) is a potent endogenous inhibitor of angiogenesis, and a promising anticancer agent. We have previously shown that PEDF can be phosphorylated, and that distinct phosphorylations differentially regulate its physiological functions. We also demonstrated that triple phosphomimetic mutant (EEE-PEDF), has significantly increased antiangiogenic activity, and is much more efficient than WT-PEDF in inhibiting neovascularization and tumor growth. The enhanced antiangiogenic effect was associated with a direct ability to facilitate apoptosis of tumor-residing endothelial cells (EC), and subsequently, disruption of intratumoral vascularization. In the present report, we elucidated the molecular mechanism by which EEE-PEDF exerts more profound effects at the cellular level.

Authors : Konson Alexander , Pradeep Sunila , D'Acunto Cosimo Walter , Seger Rony ,

Related products :

Catalog number Product name Quantity
26-202 This protein can induce apoptosis in a caspase-dependent manner and plays a role in p53_TP53-dependent apoptosis. 0.05 mg
RCY-580 Recombinant Human Pigment Epithelium-Derived Factor 5
cyt-552 Recombinant Human Pigment Epithelium-Derived Factor, His Tag 20
EGP041 Pigment Epithelium Derived Factor Elisa Kit 96T
cyt-580 Recombinant Human Pigment Epithelium-Derived Factor 1mg
cyt-553 Recombinant Human Pigment Epithelium-Derived Factor, HEK 2
cyt-552 Recombinant Human Pigment Epithelium-Derived Factor, His Tag 5
cyt-553 Recombinant Human Pigment Epithelium-Derived Factor, HEK 100
cyt-552 Recombinant Human Pigment Epithelium-Derived Factor, His Tag 1mg
EP135 Pigment Epithelium Derived Factor Elisa Kit 96T
RCY-552 Recombinant Human Pigment Epithelium-Derived Factor, His Tag 5
RCY-553 Recombinant Human Pigment Epithelium-Derived Factor, HEK 2
cyt-553 Recombinant Human Pigment Epithelium-Derived Factor, HEK 10
cyt-580 Recombinant Human Pigment Epithelium-Derived Factor 5
ER1250 Pigment Epithelium Derived Factor Elisa Kit 96T
EM456 Pigment epithelium-derived factor Elisa Kit 96T
cyt-580 Recombinant Human Pigment Epithelium-Derived Factor 20
EH1048 Pigment epithelium-derived factor Elisa Kit 96T
EM1280 Pigment Epithelium Derived Factor Elisa Kit 96T
CG77 Pigment epithelium-derived factor SERPIN F1 lmg
EH3547 Pigment Epithelium Derived Factor Elisa Kit 96T
CG77 Pigment epithelium-derived factor SERPIN F1 500
E02P0084 Rat Pigment Epithelium Derived Factor ELISA 96T/kit
E0784m ELISA kit Caspin,Mouse,Mus musculus,PEDF,Pedf,Pigment epithelium-derived factor,Sdf3,SDF-3,Serpin F1,Serpinf1,Stromal cell-derived factor 3 96T
U0784m CLIA Caspin,Mouse,Mus musculus,PEDF,Pedf,Pigment epithelium-derived factor,Sdf3,SDF-3,Serpin F1,Serpinf1,Stromal cell-derived factor 3 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur