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Pubmed ID :28478085
Publication Date : //

Influence of haplotypes, gene expression and soluble levels of L-selectin on the risk of acute coronary syndrome.


L-selectin gene (SELL) is a candidate gene for the development of acute coronary syndrome (ACS) that contributes to endothelial dysfunction. The -642C>T (rs2205849) and 725C>T (rs2229569) polymorphisms have been associated with changes in gene expression, ligand affinity and increased risk of cardiovascular disease. The aim of this study was to investigate the association between the haplotypes constructed with the -642C>T and 725C>T polymorphisms of the SELL gene, the expression levels of its mRNA and the serum levels of soluble L-selectin with ACS.

Authors : Sandoval-Pinto Elena , Padilla-Gutiérrez Jorge Ramón , Hernández-Bello Jorge , Martínez-Fernández Diana Emilia , Valdés-Alvarado Emmanuel , Muñoz-Valle José Francisco , Flores-Salinas H E , Valle Yeminia ,

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