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Index / Biovis / Caspase_12 Antibody / Product Detail : 3282-100 Caspase_12 Antibody
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Nov
21th

#3282-100 Caspase_12 Antibody

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  Price : 385   EUR
437   USD
298   GBP
1617   Zloty
51530   JPY
2970   NOK
3182   SEK
435   CHF

Product name : Caspase_12 Antibody

Catalog number : 3282-100

Quantity: 100 µg

Availability: Yes

Supplier name : Biovis

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About this Product :

Caspase_12 Antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Caspase_12 Antibody.
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More Details about

Antibody Target: Caspase -12

Alternative Name: CASP12 , CASP12P1

Host: Rabbit

Antibody Type: Polyclonal

Isotype: Rabbit IgG

Immunogen: Synthetic peptide corresponding to residues surrounding amino acid 310 of mouse caspase-12

Accession#: NM_009808

Gene ID: 12364

Appearance: Colorless liquid

Concentration: 0.2 mg/ml

Formulation: 100 µg (0.2 mg/ml) affinity purified rabbit anti-caspase-12 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified

Species Reactivity: mouse, rat

Application: Western blot

Application & Usage: Western blotting (0.5-4 µg/ml). It detects procaspase-12 (55 kDa) and cleavage caspase-12 (36 kDa) on SDS-PAGE immunoblots. However, the optimal conditions should be determined individually.

Storage Temp.: -20 °C

Shipping: gel pack

Background Descriptions: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains two pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is located to the ER, but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium hemeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is localized to the ER with several proteins that are involved in Alzheimer’s disease including gamma-secretase presenilin and β-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-β. Caspase-12 is ubiquitously expressed in mouse tissues.

Handling: The antibody solution should be gently mixed before use.

Usage: For Research Use Only! Not to be used in humans.

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